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where C is the concentration [mol/m 3]; t is the time [s]; K is the clearance [m 3 /s]; V is the volume of distribution [m 3]; From the above definitions it follows that is the first derivative of concentration with respect to time, i.e. the change in concentration with time.
Standardized Kt/V, also std Kt/V, is a way of measuring dialysis adequacy. It was developed by Frank Gotch and is used in the United States to measure dialysis. Despite the name, it is quite different from Kt/V. In theory, both peritoneal dialysis and hemodialysis can be quantified with std Kt/V.
˙ is the mass generation rate of the substance - assumed to be a constant, i.e. not a function of time (equal to zero for exogenous (foreign) substances/drugs) [mmol/min] or [mol/s] t is dialysis time or time since injection of the substance/drug [min] or [s] V is the volume of distribution or total body water [L] or [m 3]
In nephrology, dialysis adequacy is the measurement of renal dialysis for the purpose of determining dialysis treatment regime and to better understand the pathophysiology of renal dialysis. [1] It is an area of considerable controversy in nephrology .
The relative efficiency of two unbiased estimators is defined as [12] (,) = [()] [()] = ()Although is in general a function of , in many cases the dependence drops out; if this is so, being greater than one would indicate that is preferable, regardless of the true value of .
Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of filtering the blood of a person whose kidneys are not working normally. This type of dialysis achieves the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of kidney failure.
The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula was first published in May 2009. It was developed in an effort to create a formula more accurate than the MDRD formula, especially when actual GFR is greater than 60 mL/min per 1.73 m 2. This is the formula currently recommended by NICE in the UK. [27]
Renal replacement therapy includes dialysis (hemodialysis or peritoneal dialysis), hemofiltration, and hemodiafiltration, which are various ways of filtration of blood with or without machines. Renal replacement therapy also includes kidney transplantation , which is the ultimate form of replacement in that the old kidney is replaced by a donor ...