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COVID-19 vaccine clinical research uses clinical research to establish the characteristics of COVID-19 vaccines. These characteristics include efficacy , effectiveness , and safety. As of November 2022 [update] , 40 vaccines are authorized by at least one national regulatory authority for public use: [ 1 ] [ 2 ]
From the early outbreak of the COVID-19 pandemic, rumors and speculation arose about the possible lab origins of SARS-CoV-2, the causative agent of the COVID-19 disease. . Different versions of the lab origin hypothesis present different scenarios in which a bat-borne progenitor of SARS-COV-2 may have spilled over to humans, including a laboratory-acquired infection of a natural or engineered vi
PubMed Central (PMC) is a free digital repository that archives open access full-text scholarly articles that have been published in biomedical and life sciences journals. As one of the major research databases developed by the National Center for Biotechnology Information (NCBI), PubMed Central is more than a document repository.
On 17 March 2020, Nature Medicine published a correspondence article titled "The proximal origin of SARS-CoV-2" that discussed the origin of the coronavirus that caused COVID-19 pandemic from genetic perspective. The article focused on analysing SARS-CoV-2's genome, and the sites that enable it to bind to human cells. [3]
Several studies found only weak signs of adaptive evolution early in the COVID-19 pandemic. [c] Kang et al. wrote that SARS-CoV-2 had exhibited relatively little genetic variation by 2021. [47] Tai et al. wrote that population expansion rather than positive selection explained the mutation frequency spectrum during the early pandemic. [49]
Transmission and life-cycle of SARS-CoV-2 causing COVID-19. Coronaviruses vary significantly in risk factor. Some can kill more than 30% of those infected, such as MERS-CoV, and some are relatively harmless, such as the common cold. [49] Coronaviruses can cause colds with major symptoms, such as fever, and a sore throat from swollen adenoids. [91]
In a press conference, Tedros remarked that the diminishing threat from COVID-19 had "allowed most countries to return to life as we knew it before COVID-19". [ 263 ] In September the WHO said it had observed "concerning" trends in COVID-19 case numbers and hospitalisations, although analysis was hampered because many countries were no longer ...
As of 2023, the COVID-19 pandemic is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV‑2). Its effect has been broad, affecting general society, the global economy, culture, ecology, politics, and other areas.
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