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Paracetamol poisoning, also known as acetaminophen poisoning, ... (p<0.01 vs untreated control group). The oral LD50 was found to be greater than 2000 mg kg-1 ...
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die.
Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [ 13 ] [ 14 ] [ 15 ] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol .
It is desirous for the value of LD 50 to be as large as possible, to decrease risk of lethal effects and increase the therapeutic window. In the above formula, TI safety increases as the difference between LD 50 and ED 50 increases—hence, a higher safety-based therapeutic index indicates a larger therapeutic window, and vice versa.
The minimum dosage at which paracetamol causes toxicity usually is 7.5 to 10g in the average person. [2] The lethal dose is usually between 10 g and 15 g. [citation needed] Concurrent alcohol intake lowers these thresholds significantly. Chronic alcoholics may be more susceptible to adverse effects due to reduced glutathione levels. [3]
The median lethal dose of a substance is defined as the dose that leads to death in 50% of the tested population. It is a significant parameter in toxicology study and indicates the acute toxicity of a particular substance. LD50 is usually expressed in the weight of the chemical administered in milligram per unit of body weight (mg/kg). [29]
This depends on the need for the effect, and also the toxicity. The toxicity and even the lethality of a drug can be quantified by the TD 50 and LD 50 respectively. Ideally, the effective dose would be substantially less than either the toxic or lethal dose for a drug to be therapeutically relevant.
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