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In the short term, paracetamol is safe and effective when used as directed. [33] Short term adverse effects are uncommon and similar to ibuprofen, [34] but paracetamol is typically safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for long-term use. [35] Paracetamol is also often used in patients who cannot tolerate NSAIDs like ibuprofen.
In contrast, paracetamol is a safe and effective medication that is taken without complications by millions of people. [52] In addition, alternative pain relief medications such as aspirin are more toxic in overdose, whereas non-steroidal anti-inflammatory drugs are associated with more adverse effects following normal use.
Paracetamol (acetaminophen) class antipyretics, which have negligible anti-inflammatory activity. Apart from paracetamol itself, the medications in this class are mainly previously marketed drugs which were withdrawn owing to safety concerns, one example of this being phenacetin. A few other medications have antipyretic effects of varying strength.
According to the scientists, it has been assumed that paracetamol was a completely safe drug to use in patients with high blood pressure.
When not contra-indicated, they are favoured over the use of paracetamol alone due to the anti-inflammatory effect they provide. [32] There is weak evidence suggesting that taking pre-operative analgesia can reduce the length of post operative pain associated with placing orthodontic spacers under local anaesthetic. [33]
Paracetamol, alternatively known by its trade names Tylenol or Panadol, also has a therapeutic index of 10. [11] Even less safe are drugs such as digoxin, a cardiac glycoside; its therapeutic index is approximately 2:1. [12]
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To be safe, if you’re vulnerable to deficiency, you should always check with your health care provider to see if you’re okay to take expired vitamins. They will steer you in the right ...
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