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The UK's National Institute for Health and Care Excellence (NICE), and the US's National Multiple Sclerosis Society, endorsed the off-label use of modafinil to alleviate fatigue associated with MS in 2022. [37] [38] MS-related fatigue is a common and often debilitating symptom experienced by people with multiple sclerosis.
The drug has been found to block the dopamine transporter (DAT) by 83%, to a greater extent than methylphenidate without unfavorable concomitant adrenergic effects. [8] The drug is an atypical DRI similarly to modafinil. [11] [1] [9] The affinities for the DAT of flmodafinil's enantiomers and modafinil have also been studied.
The drug reached phase 3 clinical trials for treatment of fatigue prior to the discontinuation of its development for this use in January 2024. [32] Aside from the preceding indications, armodafinil is currently under development for the treatment of eating disorders and, as of January 2024, is in phase 3 trials for this use.
A few medications have been studied to treat MS-related fatigue, such as amantadine [145] [146] pemoline (which is a psychostimulant also used for attention-deficit hyperactivity disorder and narcolepsy), [147] [148] or modafinil, [149] [150] [151] as well as psychological interventions of energy conservation, [152] [153] but the effects of all ...
Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders , including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
Approved for treating narcolepsy, obstructive sleep apnea, and shift work sleep disorder, modafinil is a wakefulness-promoting drug used to decrease fatigue, increase vigilance, and reduce daytime sleepiness. [1] Modafinil improves alertness, attention, long-term memory, and daily performance in people with sleep disorders. [1] [18]
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