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  2. Receptor tyrosine kinase - Wikipedia

    en.wikipedia.org/wiki/Receptor_tyrosine_kinase

    The receptors are generally activated by dimerization and substrate presentation. Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains. [4]

  3. Enzyme-linked receptor - Wikipedia

    en.wikipedia.org/wiki/Enzyme-linked_receptor

    The signaling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell. Examples of the enzymatic activity include: Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme-linked receptors are of this type. [3]

  4. Cell surface receptor - Wikipedia

    en.wikipedia.org/wiki/Cell_surface_receptor

    Enzyme-linked receptors are either enzymes themselves, or directly activate associated enzymes. These are typically single-pass transmembrane receptors, with the enzymatic component of the receptor kept intracellular. The majority of enzyme-linked receptors are, or associate with, protein kinases. G protein-coupled receptors are integral ...

  5. Receptor (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Receptor_(biochemistry)

    Receptor proteins can be classified by their location. Cell surface receptors, also known as transmembrane receptors, include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. [1] Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. [1]

  6. Cell signaling - Wikipedia

    en.wikipedia.org/wiki/Cell_signaling

    VEGF receptors are a type of enzyme-coupled receptors, specifically tyrosine kinase receptors. Enzyme-linked receptors (or catalytic receptors) are transmembrane receptors that, upon activation by an extracellular ligand, causes enzymatic activity on the intracellular side. [33]

  7. Tyrosine kinase - Wikipedia

    en.wikipedia.org/wiki/Tyrosine_kinase

    Many receptor enzymes have closely related structure and receptor tyrosine kinase activity, and it has been determined that the foundational or prototypical receptor enzyme is insulin. [2] Insulin receptor substrates IRS2 and IRS3 each have unique characteristic tissue function and distribution that serves to enhance signaling capabilities in ...

  8. G protein-coupled receptor kinase - Wikipedia

    en.wikipedia.org/wiki/G_protein-coupled_receptor...

    G protein-coupled receptor kinases (GPCRKs, GRKs) are a family of protein kinases within the AGC (protein kinase A, protein kinase G, protein kinase C) group of kinases.Like all AGC kinases, GRKs use ATP to add phosphate to Serine and Threonine residues in specific locations of target proteins.

  9. Protein kinase - Wikipedia

    en.wikipedia.org/wiki/Protein_kinase

    Some tyrosine receptor kinases (e.g., the platelet-derived growth factor receptor) can form heterodimers with other similar but not identical kinases of the same subfamily, allowing a highly varied response to the extracellular signal. Trans-autophosphorylation (phosphorylation by the other kinase in the dimer) of the kinase.