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Calcium carbonate antacid tablets. An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion, or an upset stomach. [1] Some antacids have been used in the treatment of constipation and diarrhea. [2] Marketed antacids contain salts of aluminum, calcium, magnesium, or sodium. [2]
Onset is over a few hours and effects last up to a couple of days. [4] Common side effects include constipation, abdominal pain, and nausea. [4] [3] Serious side effects may include osteoporosis, low blood magnesium, Clostridioides difficile infection, and pneumonia. [4] [3] Use in pregnancy and breastfeeding is of unclear safety. [1]
Calcium-based antacids are recommended if these changes are not effective; aluminum- and magnesium hydroxide-based antacids are also safe. [73] Antacids that contain sodium bicarbonate or magnesium trisilicate should be avoided in pregnancy. [73] Sucralfate has been studied in pregnancy and proven to be safe [73] as is ranitidine [74] and PPIs ...
New research suggests that people who take antacids may be at greater risk for migraine attacks and severe headaches. Antacids May Increase Your Risk of Migraine Attacks or Severe Headaches Skip ...
The most common side effect seen is constipation (2–3%). Less commonly reported side effects (<0.5%) include flatulence, headache, hypophosphatemia, xerostomia (dry mouth), and bezoar formation. [24] [25] [26] Use of this drug is not recommended for people with chronic kidney failure, as it might cause aluminium accumulation and toxicity.
Long-term use of NSAIDs can cause gastric erosions, which can become stomach ulcers and in extreme cases can cause severe haemorrhage, resulting in death. The risk of death as a result of GI bleeding caused by the use of NSAIDs is 1 in 12,000 for adults aged 16–45. [5] The risk increases almost twentyfold for those over 75. [5]
[1] [2] The GI cocktail is commonly prescribed in the hospital or emergency department, and has been used to help distinguish chest pain as either gastrointestinal or cardiac. [1] While it has been widely used in the treatment of dyspepsia, studies have suggested that the GI cocktail is only as effective as antacids alone.
Common side effects include headaches, diarrhea, abdominal pain, and joint pain. [5] [6] More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency. [5] Use in pregnancy appears to be safe. [5]
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