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Troponin C (red) binds Ca2+, which stabilizes the activated state, where troponin I (yellow) is no longer bound to actin. Troponin T (blue) anchors the complex on tropomyosin. Troponin is found in both skeletal muscle and cardiac muscle , but the specific versions of troponin differ between types of muscle.
Test Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury.
Troponin C is a protein which is part of the troponin complex. It contains four calcium-binding EF hands , although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments , along with actin and tropomyosin .
7134 21924 Ensembl ENSG00000114854 ENSMUSG00000091898 UniProt P63316 P19123 RefSeq (mRNA) NM_003280 NM_009393 RefSeq (protein) NP_003271 NP_033419 Location (UCSC) Chr 3: 52.45 – 52.45 Mb Chr 14: 30.93 – 30.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated ...
21925 Ensembl ENSG00000101470 ENSMUSG00000017300 UniProt P02585 P20801 RefSeq (mRNA) NM_003279 NM_009394 RefSeq (protein) NP_003270 NP_033420 Location (UCSC) Chr 20: 45.82 – 45.83 Mb Chr 2: 164.62 – 164.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene. Troponin (Tn), is a key protein complex in ...
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
Consequently, intracellular Ca2+ levels rise. The interaction between Ca2+ and Troponin C (TnC) is significant, as it prepares muscle fibres for the sliding filament mechanism, which explains muscle contraction. [5] With increased Ca2+ levels, interactions between Ca2+ and TnC intensify, leading to stronger contractions of the myocardiocytes. [6]
~50% of 8 AM value C-peptide: fasting 0.5-2.0 × 10 −9: maximum 4 × 10 −9: C-reactive protein: Plasma protein 6.8-820 × 10 −8: Creatine: Assists muscle cell energy supply male 1.7-5.0 × 10 −6: female 3.5-9.3 × 10 −6: Creatinine: male 0.8-1.5 × 10 −5: female 0.7-1.2 × 10 −5: Cyanide: nonsmokers 4 × 10 −9: smokers 6 × 10 ...
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