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  2. Advanced glycation end-product - Wikipedia

    en.wikipedia.org/wiki/Advanced_glycation_end-product

    Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. [1] They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases , such as diabetes , atherosclerosis , chronic kidney disease , and Alzheimer's disease .

  3. N(6)-Carboxymethyllysine - Wikipedia

    en.wikipedia.org/wiki/N(6)-Carboxymethyllysine

    N(6)-Carboxymethyllysine (CML), also known as N ε-(carboxymethyl)lysine, is an advanced glycation endproduct (AGE). CML has been the most used marker for AGEs in food analysis. CML has been the most used marker for AGEs in food analysis.

  4. Category:Advanced glycation end-products - Wikipedia

    en.wikipedia.org/wiki/Category:Advanced...

    Pages in category "Advanced glycation end-products" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. A.

  5. RAGE (receptor) - Wikipedia

    en.wikipedia.org/wiki/RAGE_(receptor)

    Schematic of the relation between an immunoglobulin and RAGE Schematic of the RAGE gene and its products. RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor [5] of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. [6] Its name comes from its ability to bind advanced glycation endproducts (), which ...

  6. Polyol pathway - Wikipedia

    en.wikipedia.org/wiki/Polyol_pathway

    Sorbitol may also glycate nitrogens on proteins, such as collagen, and the products of these glycations are referred-to as AGEs - advanced glycation end-products. AGEs are thought to cause disease in the human body, one effect of which is mediated by RAGE (receptor for advanced glycation end-products) and the ensuing inflammatory responses induced.

  7. Glucosepane - Wikipedia

    en.wikipedia.org/wiki/Glucosepane

    Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. [1] It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the extracellular matrix (ECM) and crystallin of the eyes. [2]

  8. Pimagedine - Wikipedia

    en.wikipedia.org/wiki/Pimagedine

    Pimagedine was under development as a drug for kidney diseases by the pharmaceutical company Alteon (now known Synvista Therapeutics Inc.) that was founded in 1986. [2] In 1987, Alteon acquired a license to intellectual property relating to AGE inhibition from Rockefeller University. [3]

  9. Biogerontology - Wikipedia

    en.wikipedia.org/wiki/Biogerontology

    The cross-linking theory proposes that advanced glycation end-products (stable bonds formed by the binding of glucose to proteins) and other aberrant cross-links accumulating in aging tissues is the cause of aging. The crosslinking of proteins disables their biological functions.