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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Iron is available over the counter as a single entity supplement in an iron salt form or in combination with vitamin supplements and is commonly used in the treatment of anemias. [ 1 ] [ 2 ] Overdoses on iron can be categorized as unintentional ingestion which is predominantly associated with children or intentional ingestion involving suicide ...
“Do not take iron just because you are experiencing these symptoms, or you risk iron overload, which can bring different problems to the surface,” says Indhira Ghyssaert, M.D., a family ...
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Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or portal macrophages) rather than parenchymal iron overload (within hepatocytes). [7] There are several methods available for diagnosing and monitoring hemosiderosis including: Serum ferritin ...
Iron deficiency can cause a slew of symptoms, including fatigue, brain fog, and dizziness. It can even lead to serious health complications over ... Hemochromatosis, a.k.a. iron overload, can ...
Hepcidin is the master regulator of iron metabolism and, therefore, most genetic forms of iron overload can be thought of as relative hepcidin deficiency in one way or another. For instance, a severe form of iron overload, juvenile hemochromatosis, is a result of severe hepcidin deficiency.
"Too little iron can cause iron deficiency anemia," Dr. Cox continued. "Anemia can lead to complications, such as heart attack or stroke , due to decreased oxygen delivery and blood volume."
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