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The eutomer is the enantiomer having the desired pharmacological activity, [4] e.g., as an active ingredient in a drug. The distomer , on the other hand, is the enantiomer of the eutomer which may have undesired bioactivity or may be bio-inert.
One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects. [1] The desired enantiomer is known as an eutomer while the undesired enantiomer is known as the distomer. [ 2 ]
An example of such an enantiomer is the sedative thalidomide, which was sold in a number of countries around the world from 1957 until 1961. It was withdrawn from the market when it was found to cause birth defects. One enantiomer caused the desirable sedative effects, while the other, unavoidably [23] present in equal quantities, caused birth ...
In chemistry, racemization is a conversion, by heat or by chemical reaction, of an optically active compound into a racemic (optically inactive) form. This creates a 1:1 molar ratio of enantiomers and is referred to as a racemic mixture (i.e. contain equal amount of (+) and (−) forms).
It is an important tool in the production of optically active compounds, including drugs. [3] Another term with the same meaning is optical resolution . The use of chiral resolution to obtain enantiomerically pure compounds has the disadvantage of necessarily discarding at least half of the starting racemic mixture.
Most people naturally have enough HGH. For those with a growth hormone deficiency (or a few other health conditions), GH therapy may offer a solution.
Paclobutrazol (PBZ) is the ISO common name for an organic compound that is used as a plant growth retardant and triazole fungicide. [2] [3] It is a known antagonist of the plant hormone gibberellin, acting by inhibiting gibberellin biosynthesis, reducing internodal growth to give stouter stems, increasing root growth, causing early fruitset and increasing seedset in plants such as tomato and ...
Polish ski jumper Andrezj Stekala penned a heartbreaking post on social media mourning his partner of eight years, who died in November. Stekala, 29, came out as gay in the emotional post on Jan ...