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2. Diphenhydramine - Wikipedia

   en.wikipedia.org/wiki/Diphenhydramine

   Diphenhydramine is a first-generation antihistamine used to treat several conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms. [19] [20] Diphenhydramine also has local anesthetic properties, and has been used as such in people allergic to common local anesthetics such as ...

3. Antiemetic - Wikipedia

   en.wikipedia.org/wiki/Antiemetic

   An antiemetic is a drug that is effective against vomiting and nausea.Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.

4. H1 antagonist - Wikipedia

   en.wikipedia.org/wiki/H1_antagonist

   Diphenhydramine was the prototypical agent in this group. ... Compounds from this group are often used for motion sickness, vertigo, nausea, and vomiting.

5. Dimenhydrinate - Wikipedia

   en.wikipedia.org/wiki/Dimenhydrinate

   Dimenhydrinate is an over-the-counter (OTC) first-generation antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. [2] Dimenhydrinate can also be used for Insomnia, but this is an off label use. [5]

6. Chemoreceptor trigger zone - Wikipedia

   en.wikipedia.org/wiki/Chemoreceptor_trigger_zone

   The neurotransmitters implicated in the control of nausea and vomiting include acetylcholine, dopamine, histamine (H1 receptor), substance P (NK-1 receptor), and serotonin (5-HT3 receptor). There are also opioid receptors present, which may be involved in the mechanism by which opiates cause nausea and vomiting.

7. 5-HT3 antagonist - Wikipedia

   en.wikipedia.org/wiki/5-HT3_antagonist

   The 5-HT 3 receptor antagonists suppress vomiting and nausea by inhibiting serotonin binding to the 5-HT 3 receptors. The highest concentration of 5-HT 3 receptors in the central nervous system are found in the STN and chemoreceptor trigger zone (CTZ), and 5-HT 3 antagonists may also suppress vomiting and nausea by acting at these sites. [29]