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Structures of GM1, GM2, GM3 gangliosides. GM3 (monosialodihexosylganglioside) is a type of ganglioside. The letter G refers to ganglioside, and M is for monosialic acid as it has only one sialic acid group. The numbering is based on its relative mobility in electrophoresis among other monosialic gangliosides. [1]
The secreted toxin attaches to the surface of the host mucosa cell by binding to GM1 gangliosides. GM1 consists of a sialic acid-containing oligosaccharide covalently attached to a ceramide lipid. The A1 subunit of this toxin will gain entry to intestinal epithelial cells with the assistance of the B subunit via the GM1 ganglioside receptor.
This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. References [ edit ]
The GM1 gangliosidoses, usually shortened to GM1, are gangliosidoses caused by mutation in the GLB1 gene resulting in a deficiency of beta-galactosidase.The deficiency causes abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells, resulting in progressive neurodegeneration.
(Reuters) -The U.S. Food and Drug Administration has approved Ionis Pharmaceuticals' drug to treat a rare genetic disorder, making it the company's first wholly-owned drug, the health regulator's ...
A ganglioside is a molecule composed of a glycosphingolipid ... Structures of GM1, GM2, GM3. One NANA ("M") GM1; GM2; GM3; Two NANAs ("D") GD1a; GD1b; GD2; GD3; Three ...
14667 Ensembl ENSG00000196743 ENSMUSG00000000594 UniProt P17900 Q60648 RefSeq (mRNA) NM_001167607 NM_000405 NM_010299 RefSeq (protein) NP_000396 NP_001161079 NP_034429 Location (UCSC) Chr 5: 151.21 – 151.27 Mb Chr 11: 54.99 – 55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse GM2 ganglioside activator also known as GM2A is a protein which in humans is encoded by the GM2A gene ...
In organic chemistry, GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic (as in it has one sialic acid), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 gangliosidoses such as Tay–Sachs disease. [1]