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Oleylamine is an organic compound with a molecular formula C 18 H 35 NH 2. [1] It is an unsaturated fatty amine related to the fatty acid oleic acid . The pure compound is a clear and colorless liquid.
Fatty amines are commonly prepared from fatty acids; which are themselves obtained from natural sources, typically seed-oils.The overall reaction is sometimes referred to as the Nitrile Process [3] and begins with a reaction between the fatty acid and ammonia at high temperature (>250 °C) and in the presence of a metal oxide catalyst (e.g., alumina or zinc oxide) to give the fatty nitrile.
In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. [4] [5] It has been considered as a treatment for mood and sleep disorders, as well as cannabinoid-regulated depression. [6] [7]
Oleoylethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist.It is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.
Hydroxylamine can also be used to highly selectively cleave asparaginyl-glycine peptide bonds in peptides and proteins. [32] It also bonds to and permanently disables (poisons) heme-containing enzymes. It is used as an irreversible inhibitor of the oxygen-evolving complex of photosynthesis on account of its similar structure to water.
Fatty alcohols are mainly used in the production of detergents and surfactants. Due to their amphipathic nature, fatty alcohols behave as nonionic surfactants. They find use as co-emulsifiers, emollients and thickeners in cosmetics and food industry. About 50% of fatty alcohols used commercially are of natural origin, the remainder being ...
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SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2] [3] [4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine.