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  2. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  3. Narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Narcolepsy

    Measuring orexin levels in a person's cerebrospinal fluid sampled in a spinal tap may help in diagnosing narcolepsy, with abnormally low levels serving as an indicator of the disorder. [47] This test can be useful when MSLT results are inconclusive or difficult to interpret. [48]

  4. Orexin antagonist - Wikipedia

    en.wikipedia.org/wiki/Orexin_antagonist

    An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the orexin receptors, OX 1 and OX 2. [1] Medical applications include treatment of sleep disorders such as ...

  5. Daridorexant - Wikipedia

    en.wikipedia.org/wiki/Daridorexant

    The endogenous orexin neuropeptides, orexin A and orexin B, are involved in the regulation of sleep–wake cycles and act to promote wakefulness. [33] [16] [7] Deficiency of orexin signaling is thought to be the primary cause of the sleep disorder narcolepsy. [33] [16] Disturbances in orexin signaling may also be involved in insomnia. [33]

  6. Orexin receptor - Wikipedia

    en.wikipedia.org/wiki/Orexin_receptor

    Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors ...

  7. 25 of the very best deals from Nordstrom's Half-Yearly Sale ...

    www.aol.com/lifestyle/the-very-best-deals-from...

    One of the best post-Christmas sales we look forward to every year is Nordstrom's Half-Yearly Sale, which typically kicks off the day after Christmas and lasts for a couple of weeks.Ring in the ...

  8. Newborn Allegedly Dies After Mother's Induction Is Delayed ...

    www.aol.com/newborn-allegedly-dies-mothers...

    But Ava-Lea died at 35 hours old, a direct result of oxygen deprivation and inhaling meconium, according to the BBC. Irwin Mitchell/SWNS. Chelsea Wootton takes a selfie while pregnant.

  9. Hypocretin (orexin) receptor 2 - Wikipedia

    en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_2

    Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.