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Dysthymia (/ d ɪ s ˈ θ aɪ m i ə / dihs-THIY-mee-uh), also known as persistent depressive disorder (PDD), [3] is a mental and behavioral disorder, [5] specifically a disorder primarily of mood, consisting of similar cognitive and physical problems as major depressive disorder, but with longer-lasting symptoms.
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
Research on pharmaceutical treatment of double depression in particular is sparse. Certain medications, such as fluoxetine, were found in numerous studies to be effective at reducing symptom severity; however, these studies involved open-label trials, double-blind randomized trials that lack placebo conditions, and small sample sizes.
The treatment of dysthymia is largely the same as for major depression, including antidepressant medications and psychotherapy. [8] Double depression can be defined as a fairly depressed mood (dysthymia) that lasts for at least two years and is punctuated by periods of major depression. [27]
Postpartum depression occurs after the delivery of an infant and mimics typical depressive symptoms, although some symptoms are different: ideas of infanticide, paranoia, and compulsive thoughts. Interpersonal therapy has been thought to be a good potential treatment for postpartum depression because it is short-term and focused on present life ...
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
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