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Bufotenin, also known as dimethylserotonin or as 5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT), is a tryptamine derivative, more specifically, a dimethyltryptamine (DMT) analogue, related to the neurotransmitter serotonin. It is an alkaloid found in some species of mushrooms, plants and toads, especially the skin.
4-HO-TMT is a quaternary trimethyl ammonium compound, and as a result, is less likely to be able to cross the blood–brain barrier (BBB) and enter the central nervous system than other tryptamines. [ 1 ] [ 4 ] Accordingly, 4-HO-TMT showed no ability to cross an artificial BBB-like membrane in a study. [ 2 ]
4-HO-5-MeO-DMT (psilomethoxin) mushrooms derived from Psilocybe cubensis mycelium in substrate with added 5-MeO-DMT. [1] [2] 4-HO-DET and 4-PO-DET mushrooms derived from Psilocybe cubensis mycelium in substrate with added DET. [3] [4] 4-HO-DiPT mushrooms derived from Psilocybe cubensis mycelium in substrate with added DiPT. [2] 4-HO-DPT ...
5-MeO-isoDMT, or 5-OMe-isoDMT, also known as 5-methoxy-N,N-dimethylisotryptamine, is a putatively non-hallucinogenic serotonin 5-HT 2A receptor agonist and psychoplastogen of the isotryptamine group.
[1] [2] [4] [6] However, isoDMT retains significant activity at the serotonin 5-HT 2 receptors and shows psychoplastogenic effects comparable to those of serotonergic psychedelics in preclinical research. [7] [6] [8] [9] Its affinities (K i) for the serotonin 5-HT 2 receptors have been reported to be 600–650 nM for 5-HT 2A and 720 nM at 5-HT ...
5-MeO-DMT, also known as 5-methoxy-N,N-dimethyltryptamine, is a substituted tryptamine derivative. It is the 5-methoxylated derivative of N,N-dimethyltryptamine (DMT), the N,N-dimethylated derivative of 5-methoxytryptamine (5-MT; mexamine), and the O-methylated derivative of bufotenin (5-HO-DMT). It has a relatively high experimental log P of 3 ...
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
O-Acetylbufotenine, or bufotenine O-acetate, also known as 5-acetoxy-N,N-dimethyltryptamine (5-AcO-DMT) or O-acetyl-N,N-dimethylserotonin, is a synthetic tryptamine derivative and putative serotonergic psychedelic.
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