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Dibromobenzene isomers Common name and systematic name 1,2-Dibromobenzene: 1,3-Dibromobenzene [1] 1,4-Dibromobenzene [2] [3] [4] Structure Molecular formula: C 6 H 4 Br 2: Molar mass: 235.906 g/mol Appearance colorless liquid colorless liquid white solid CAS number [583-53-9] [108-36-1] [106-37-6] Properties Density and phase: 1.9940 g/ml ...
1,2-Dibromobenzene (o-dibromobenzene) is an aryl bromide and isomer of dibromobenzene. It is one of three isomers, the others being 1,3- and 1,4-dibromobenzene. It is a colorless liquid, although impure samples appear yellowish. The compound is a precursor to many 1,2-disubstituted derivatives of benzene.
Bromobenzenes may be carboxylated into carboxylic acids using carbon monoxide.The reaction takes place in a two-phase mixture of p-xylene and water as solvent, in the presence of catalytic PdCl
1,3-Dibromobenzene has been used as a starting material in the synthesis of antiviral Lufotrelvir, in human clinical trials for the treatment of COVID-19. [3] The first step is formylation of 1,3-dibromobenzene to 2,6-dibromobenzaldehyde, by lithiation with lithium diisopropylamide in THF , followed by quenching with dimethylformamide .
1,4-Dibromobenzene (p-dibromobenzene) is an aryl bromide and isomer of dibromobenzene that is solid at room temperature. It has a strong smell similar to that of the lighter chlorine analogue. It can be used as a precursor to the dye 6,6-dibromoindigo. [4]
From 1,2,4,5-tetrabromobenzene, a 1,4-monoarine can be prepared in-situ with one equivalent of n-butyllithium by bromine abstraction, which reacts immediately with furan to form 6,7-dibromo-1,4-epoxy-1,4-dihydronaphthalene (6,7-dibromonaphthalene-1,4-endoxide) in 70% yield.
3. Keebler Fudge Magic Middles. Neither the chocolate fudge cream inside a shortbread cookie nor versions with peanut butter or chocolate chip crusts survived.
Bromobenzene is prepared by the action of bromine on benzene in the presence of Lewis acid catalysts such as aluminium chloride or ferric bromide. [3]Bromobenzene is used to introduce a phenyl group into other compounds.