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Examples of epithelial dysplasia include cervical intraepithelial neoplasia – a disorder commonly detected by an abnormal pap smear) consisting of an increased population of immature (basal-like) cells which are restricted to the mucosal surface, and have not invaded through the basement membrane to the deeper soft tissues.
Epithelial cells form the lining of the urinary tract. Three types may occur in urine: squamous epithelial cells, transitional epithelial cells and renal tubular epithelial cells. Some laboratories do not distinguish between the three types of cells and simply report "epithelial cells" in general. [104]
Normal squamous cells Dysplastic cells. Dysplasia is any of various types of abnormal growth or development of cells (microscopic scale) or organs (macroscopic scale), and the abnormal histology or anatomical structure(s) resulting from such growth. [1] Dysplasias on a mainly microscopic scale include epithelial dysplasia and fibrous dysplasia ...
Low-grade squamous intraepithelial lesion (LGSIL or LSIL) High grade squamous intraepithelial lesion (HGSIL or HSIL) Squamous cell carcinoma; Atypical Glandular Cells not otherwise specified (AGC-NOS) Atypical Glandular Cells, suspicious for AIS or cancer (AGC-neoplastic) Adenocarcinoma in situ (AIS) The results are calculated differently ...
"Dyskaryosis" is a term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which some of the epithelial cells near the external orifice show abnormalities in their cellular nuclei. These changes are often quite subtle; often seen as temporary changes between the ages of fifteen and twenty-five.
This system provides a uniform way to describe abnormal epithelial cells and determine specimen quality, thus providing clear guidance for clinical management. These abnormalities were classified as squamous or glandular and then further classified by the stage of dysplasia: atypical cells, mild, moderate, severe, and carcinoma. [13]
Such an epithelial transition zone may have more ambiguous stem cell fate signalling, and thus may be vulnerable to carcinogenesis. [26] A number of epithelial transition zones, e.g. ectocervix junction, gastro-duodenal junction, are implicated in the development of different epithelial cancers. [35] Opposing:
The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), [1] cervical smear (BE), cervical screening (BE), [2] or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or, more rarely, anus (in both men and women). [3]