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An orexigenic, or appetite stimulant, is a drug, hormone, or compound that increases appetite and may induce hyperphagia. This can be a medication or a naturally occurring neuropeptide hormone, such as ghrelin , orexin or neuropeptide Y , [ 1 ] [ 2 ] which increases hunger and therefore enhances food consumption .
These hormones, unknown at the time of Cannon and Washburn's work, have since been identified as crucial players in the complex system of appetite regulation. Ghrelin, often referred to as the "hunger hormone," is now known to be secreted by the stomach and stimulates appetite, while leptin, produced by fat cells, signals satiety to the brain.
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Later studies showed that appetite regulation is an immensely complex process involving the gastrointestinal tract, many hormones, and both the central and autonomic nervous systems. [15] The circulating gut hormones that regulate many pathways in the body can either stimulate or suppress appetite. [16]
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A crossword (or crossword puzzle) is a word game consisting of a grid of black and white squares, into which solvers enter words or phrases ("entries") crossing each other horizontally ("across") and vertically ("down") according to a set of clues. Each white square is typically filled with one letter, while the black squares are used to ...
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