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2. Selexipag - Wikipedia

   en.wikipedia.org/wiki/Selexipag

   Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). [3] [4] Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. [5]

3. Macitentan - Wikipedia

   en.wikipedia.org/wiki/Macitentan

   Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial hypertension (PAH). [5] Macitentan is a dual endothelin receptor antagonist, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ET A and ET B . [ 5 ]

4. Merck's therapy for rare lung condition shown to help reduce ...

   www.aol.com/news/mercks-therapy-rare-lung...

   Merck said its drug met the main goal of significantly reducing the time to disease worsening, lung transplantation or death in a late-stage study of 172 patients with advanced stages of the ...

5. Arena Pharmaceuticals - Wikipedia

   en.wikipedia.org/wiki/Arena_Pharmaceuticals

   The company has small molecule drugs in development for possible clinical utility in multiple therapeutic areas. The company's most advanced investigational clinical programs are ralinepag (formerly APD811) in testing for pulmonary arterial hypertension (PAH), etrasimod (formerly APD334) in evaluation for inflammatory indications and APD371 for ...

6. What You Need to Know About PAH Drugs in 2014 - AOL

   www.aol.com/2013/12/31/what-you-need-to-know...

   A host of newly approved drugs for pulmonary arterial hypertension, or PAH, means 2014 will be a battleground for market share in the multibillion-dollar indication. Among those competing will be ...

7. Arena (ARNA) Out-Licenses Rights to PAH Drug, Stock Up 22%

   www.aol.com/news/arena-arna-licenses-rights-pah...

   Arena (ARNA) inks a deal to out-license global rights to its phase III candidate, ralinepag, to United Therapeutics. Shares of the company rally 22% following this news.

8. PAH clearance - Wikipedia

   en.wikipedia.org/wiki/PAH_clearance

   Para-aminohippurate (PAH) clearance is a method used in renal physiology to measure renal plasma flow, which is a measure of renal function. [citation needed]PAH is completely removed from blood that passes through the kidneys (PAH undergoes both glomerular filtration and tubular secretion), and therefore the rate at which the kidneys can clear PAH from the blood reflects total renal plasma flow.

9. Actelion - Wikipedia

   en.wikipedia.org/wiki/Actelion

   By ignoring the laws and regulations set by Congress, to prevent pharmaceutical companies from increasing the demand and prices of their drugs, and using information obtained from Caring Voice Coalition to financially support patients who were buying only its own drugs, Actelion was able to increase its drug prices to extraordinarily high ...