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Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of three types of Salmonella enterica. [1] Symptoms usually begin 6–30 days after exposure and are the same as those of typhoid fever .
Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called Salmonella typhi. [2] [3] Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. [4] [5] Often there is a gradual onset of a high fever over several days. [4]
Specific types of Salmonella can result in typhoid fever or paratyphoid fever. [1] [3] Typhoid fever and paratyphoid fever are specific types of salmonellosis, known collectively as enteric fever, [6] and are, respectively, caused by salmonella typhi and paratyphi bacteria, which are only found in humans. [7]
Typhoid fever causes 11 million infections and more than 100,000 deaths per year, and is most prevalent in south Asia – which accounts for 70% of the global disease burden.
In 2000, typhoid fever caused an estimated 21.7 million illnesses and 217,000 deaths. [1] It occurs most often in children and young adults between 5 and 19 years old. [2] In 2013, it resulted in about 161,000 deaths – down from 181,000 in 1990. [3]
Enteric fever is a medical term encompassing two types of salmonellosis, which, specifically, are typhoid fever and paratyphoid fever. [1] Enteric fever is a potentially life-threatening acute febrile systemic infection and is diagnosed by isolating a pathogen on culture.
Rose spots on the chest of a patient with typhoid fever. Rose spots are blanching red macules 2-4 millimeters in diameter occurring in patients with enteric fever (which includes typhoid and paratyphoid). These fevers occur following infection by Salmonella typhi and Salmonella paratyphi respectively.
Intestinal infectious diseases include a large number of infections of the bowels, including cholera, typhoid fever, paratyphoid fever, other types of salmonella infections, shigellosis, botulism, gastroenteritis, and amoebiasis among others. [1] Typhoid and paratyphoid resulted in 221,000 deaths in 2013 down from 259,000 deaths in 1990. [2]
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