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Inbreeding is also used to reveal deleterious recessive alleles, which can then be eliminated through assortative breeding or through culling. In plant breeding, inbred lines are used as stocks for the creation of hybrid lines to make use of the effects of heterosis. Inbreeding in plants also occurs naturally in the form of self-pollination.
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PLINK [1] is a free, commonly used, open-source whole-genome association analysis toolset designed by Shaun Purcell. The software is designed flexibly to perform a wide range of basic, large-scale genetic analyses. PLINK currently supports following functionalities: data management;
Wright was the inventor/discoverer of the inbreeding coefficient and F-statistics, standard tools in population genetics. He was the chief developer of the mathematical theory of genetic drift , [ 27 ] which is sometimes known as the Sewall Wright effect, [ 29 ] cumulative stochastic changes in gene frequencies that arise from random births ...
The effect of inbreeding in the resulting sub-populations could be studied by measuring the runs of homozygosity in different individuals. [ 4 ] In clinical laboratory testing, the detection of ROH in itself does not indicate a particular genetic disorder but indicates an increased risk of autosomal recessive inherited diseases. [ 5 ]
Inbreeding – Reproduction by closely related organisms; Inbreeding avoidance – Evolutionary biology concept of prevention of negative inbreeding effects; Inbreeding depression – Reduced fitness as a result of inbreeding; Incest – Sexual activity between immediate family members or people considered too closely related to marry