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DSP and its symptoms usually set in within about half an hour of ingesting infected shellfish, and last for about one day. The causative poison is okadaic acid, which inhibits intestinal cellular dephosphorylation. [1] This causes the cells to become very water-permeable and the host to profusely defecate into a high risk of dehydration.
Shellfish poisoning includes four syndromes that share some common features and are primarily associated with bivalve molluscs (such as mussels, clams, oysters and scallops.) [1] As filter feeders, these shellfish may accumulate toxins produced by microscopic organisms, such as cyanobacteria, diatoms and dinoflagellates.
Shellfish containing 80 or more micrograms of saxitoxin per 100g of edible shellfish tissue are deemed to be unsafe for human consumption. [16] Currently, there is no antidote for PSP neurotoxins. Most PSP patients suffer only minor symptoms, these lasting until the toxin is eliminated from the body.
Okadaic acid, C 44 H 68 O 13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. [1] One of the primary causes of diarrhetic shellfish poisoning, okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
PSP is the most common and severe form of shellfish poisoning and is caused by neurotoxins, called saxitoxins or paralytic shellfish toxins, that are naturally produced by marine algae, called ...
Symptoms included nausea, vomiting, and diarrhea for 2–5 days prior to full recovery. Analysis of the shellfish revealed five AZA analogues, AZA1-5, with most of the toxin concentrated in the digestive glands [8] [9] at levels exceeding 30 μg/g (estimated at 6 μg/g whole mussel meat). The AZAs persisted in the mussels at elevated levels for ...
Saxitoxin is a neurotoxin naturally produced by certain species of marine dinoflagellates (Alexandrium sp., Gymnodinium sp., Pyrodinium sp.) and freshwater cyanobacteria (Dolichospermum cicinale sp., some Aphanizomenon spp., Cylindrospermopsis sp., Lyngbya sp., Planktothrix sp.) [1] [2] Saxitoxin accumulates in "planktivorous invertebrates, including mollusks (bivalves and gastropods ...
Amnesic shellfish poisoning (ASP) is an illness caused by consumption of shellfish that contain the marine biotoxin called domoic acid. [1] In mammals , including humans, domoic acid acts as a neurotoxin , causing permanent short-term memory loss , brain damage , and death in severe cases.