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Taxus brevifolia, the Pacific yew or western yew, is a species of tree in the yew family Taxaceae native to the Pacific Northwest of North America. It is a small evergreen conifer , thriving in moisture and otherwise tending to take the form of a shrub .
Taxus brevifolia. Chemicals extracted from clippings of Taxus brevifolia (Pacific yew) have been used as the basis for two chemotherapy drugs, docetaxel and paclitaxel. [8] Euphorbia peplus. Contains ingenol mebutate (Picato) which is used to treat skin cancer [9] Maytenus ovatus
Taxine can be found in Taxus species: Taxus cuspidata, T. baccata (English yew), Taxus x media, Taxus canadensis, Taxus floridana, and Taxus brevifolia (Pacific or western yew). All of these species contain taxine in every part of the plant except in the aril , [ citation needed ] the fleshy covering of the seeds (berries).
The Pacific yew (Taxus brevifolia), native to the Pacific Northwest of North America, and the Canada yew (Taxus canadensis) of Eastern and Central North America were the initial sources of paclitaxel or Taxol, a chemotherapeutic drug used in breast and lung cancer treatment and, more recently, in the production of the Taxus drug eluting stent ...
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11]
This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew (Taxus brevifolia). Not only is the synthetic reproduction of the compound itself of great commercial and scientific importance, but it also opens the way to paclitaxel derivatives ...
Paclitaxel is based on the terpenoid natural product taxol, which is isolated from Taxus brevifolia (the pacific yew tree). [109] A class of drugs widely used to lower cholesterol are the HMG-CoA reductase inhibitors, for example atorvastatin. These were developed from mevastatin, a polyketide produced by the fungus Penicillium citrinum. [110]
Decinnamoyltaxinine J is a taxane isolate derived from Taxus brevifolia. [1] Notes This page was last edited on 30 September 2024, at 12:51 (UTC). Text is available ...