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Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. [10] For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset ...
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
The treatment for hypertension will depend on how high your blood pressure is and what’s causing it. For example, elevated blood pressure and hypertension stage 1 may require some lifestyle changes.
To prevent or treat high blood pressure, the American Heart Association recommends aiming for 3,500 to 5,000 mg of potassium per day. Top sources include fruits, vegetables, low-fat dairy, fish ...
You may have read or heard about various reports that taking daily aspirin—yes, that old-time resident of your grandmother's medicine cabinet—may have benefits for modern health conditions ...
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