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Animal models of depression are research tools used to investigate depression and action of antidepressants. They are used as a simulation to investigate the symptomatology and pathophysiology of depressive illness and to screen novel antidepressants. These models provide insights into molecular, genetic, and epigenetic factors associated with ...
A number of animal models exist for depression, but they are limited in that depression involves primarily subjective emotional changes. However, some of these changes are reflected in physiology and behavior, the latter of which is the target of many animal models.
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans ...
In animal subjects, a loss of control or predictability in the subject's experiences results in a condition similar to clinical depression in humans. That is to say, if uncontrollable and unstoppable stressors are repeated for long enough, a rat subject will adopt a learned helplessness, which shares a number of behavioral and psychological ...
However this test only recently became popular in the 2000s where data has shown that animals do show a change in behavior when injected with antidepressants. TST is more reliable when done in conjunction with other depression models such as FST, learned helplessness, anhedonia models and olfactory bulbectomy. [1]
Animal psychopathology is the study of mental or behavioral disorders in non-human animals. Historically, there has been an anthropocentric tendency to emphasize the study of animal psychopathologies as models for human mental illnesses. [ 1 ]
Seasonal depression, more formally known as seasonal affective disorder (SAD), is a serious change in one’s mood often tied to fall and winter when the days get shorter and darker. Seasonal ...
If locomotion is altered compared to controls then other animal antidepressant models should be used. The term "behavioural despair test" bears an anthropomorphic connotation and is a somewhat subjective description as it is uncertain whether the test reliably gauges mood or despair.