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Cell division by mitosis is an equational division which gives rise to genetically identical cells in which the total number of chromosomes is maintained. [1] Mitosis is preceded by the S phase of interphase (during which DNA replication occurs) and is followed by telophase and cytokinesis, which divide the cytoplasm, organelles, and cell ...
Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made. After G1, the cells enter S phase during which the DNA is replicated. After S, the cell will enter G2 where the proteins required for mitosis to occur are synthesized.
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
In S phase, the chromosomes are replicated in order for the genetic content to be maintained. [18] During G 2, the cell undergoes the final stages of growth before it enters the M phase, where spindles are synthesized. The M phase can be either mitosis or meiosis depending on the type of cell.
Figure 1: Schematic of the cell cycle. outer ring: I = Interphase, M = Mitosis; inner ring: M = Mitosis, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis; not in ring: G 0 = Gap 0/Resting. Replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated.
Interphase is the phase of the cell cycle in which a typical cell spends most of its life. Interphase is the "daily living" or metabolic phase of the cell, in which the cell obtains nutrients and metabolizes them, grows, replicates its DNA in preparation for mitosis, and conducts other "normal" cell functions. [1]
A pair of sister chromatids is called a dyad. A full set of sister chromatids is created during the synthesis phase of interphase, when all the chromosomes in a cell are replicated. The two sister chromatids are separated from each other into two different cells during mitosis or during the second division of meiosis.
In molecular biology, [1] [2] [3] DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. [4] DNA replication occurs in all living organisms acting as the most essential part of biological inheritance.