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Pappalysin-1 has been shown to interact with major basic protein. [4] [5] [6]Studies conducted at the Royal London Hospital in the United Kingdom, have shown that a marker of Down's syndrome may be expressed during the first trimester and second trimester of a pregnancy term.
MoM was originally used as a method to normalize data from participating laboratories of Alpha-fetoprotein (AFP) so that individual test results could be compared. 35 years later, it is the established standard for reporting maternal serum screening results. [4] An MoM for a test result for a patient can be determined by the following:
23850 Ensembl ENSG00000116183 ENSMUSG00000073530 UniProt Q9BXP8 n/a RefSeq (mRNA) NM_020318 NM_021936 NM_001085376 RefSeq (protein) NP_064714 NP_068755 n/a Location (UCSC) Chr 1: 176.46 – 176.85 Mb Chr 1: 158.54 – 158.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is ...
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Thus for even greater accuracy of predicting risks, the outcome of the nuchal scan may be combined with the results of simultaneous maternal blood tests. In pregnancies affected by Down syndrome there is a tendency for the levels of human chorionic gonadotropin (hCG) to be increased and pregnancy-associated plasma protein A (PAPP-A) to be ...