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  2. Upadacitinib - Wikipedia

    en.wikipedia.org/wiki/Upadacitinib

    [10] [11] Upadacitinib is a Janus kinase (JAK) inhibitor that works by blocking the action of enzymes called Janus kinases. [10] [14] [11] These enzymes are involved in setting up processes that lead to inflammation, and blocking their effect brings inflammation in the joints under control. [11]

  3. Disease-modifying antirheumatic drug - Wikipedia

    en.wikipedia.org/wiki/Disease-modifying_anti...

    IL-17 inhibitor bDMARD sulfasalazine (SSZ) Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors: csDMARD tocilizumab: IL-6 receptor antagonist bDMARD tofacitinib: Janus kinase (JAK) inhibitor tsDMARD upadacitinib: Janus kinase (JAK) inhibitor tsDMARD ustekinumab: IL-12 and IL-23 inhibitor bDMARD

  4. FDA Approves AbbVie's JAK Inhibitor Application For Active ...

    www.aol.com/news/fda-approves-abbvies-jak...

    The FDA approved AbbVie Inc's (NYSE: ABBV) Rinvoq (upadacitinib; 15 mg) for active psoriatic arthritis (PsA). Like Pfizer Inc's (NYSE: PFE) approval for Xeljanz, Rinvoq's approval also covers ...

  5. AbbVie's JAK Inhibitor Rinvoq Receives Approval for RA in EU

    www.aol.com/news/abbvies-jak-inhibitor-rinvoq...

    AbbVie's (ABBV) oral JAK inhibitor, upadacitinib, receives approval in Europe for treating rheumatoid arthritis under the trade name of Rinvoq.

  6. Janus kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase_inhibitor

    A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

  7. Common Causes of Arthritis for Women (& How to Treat It) - AOL

    www.aol.com/common-causes-arthritis-women-treat...

    Small molecule DMARDs, called JAK inhibitors, like tofacitinib (Xeljanz®) and upadacitinib (Rinvoq®) Colchicine to treat or prevent gout attacks Antibiotics for bacterial infections

  8. Janus kinase - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase

    Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named " just another kinase " 1 and 2 (since they were just two of many discoveries in a PCR -based screen of kinases), [ 1 ] but were ultimately published as "Janus kinase".

  9. Can JAK Inhibitors Challenge Biologics?

    www.aol.com/news/2013-02-20-can-jak-inhibitors...

    If JAK inhibitors can show similarly impressive results, gain approval, and make a splash, then these blockbuster biologics could have some real competition. While the future is promising that "if ...

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