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Astrocytes (green) in the context of neurons (red) in a mouse cortex cell culture 23-week-old fetal brain culture human astrocyte Astrocytes (red-yellow) among neurons (green) in the living cerebral cortex. Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells.
Astrocytes stained for GFAP (green) and aquaporin-4 (purple) In a study published in 2012, [7] a group of researchers from the University of Rochester, headed by M. Nedergaard, used in-vivo two-photon imaging of small fluorescent tracers to monitor the flow of subarachnoid CSF into and through the brain parenchyma.
AQP-4 exhibits a polarized distribution in astrocytes, with a 10-times higher concentration in astrocytic endfeet, which are in contact with blood vessels, compared to non-endfoot regions. [ 40 ] In contrast to the lateral membranes of numerous epithelial cell types , astrocyte lateral membranes are devoid of tight junctions , that prevent ...
Evidence for the role of astrocytes in the integration and processing of synaptic integration presents itself in a number of ways: Astrocytes are excitable cells: In response to stimuli from any of the three components of the tripartite synapse, astrocytes are capable of producing transient changes in their intracellular calcium concentrations through release of calcium stores from the ...
Potassium spatial buffering is a mechanism for the regulation of extracellular potassium concentration by astrocytes. Other mechanisms for astrocytic potassium clearance are carrier-operated or channel-operated potassium chloride uptake. [1] The repolarization of neurons tends to raise potassium concentration in the extracellular fluid. If a ...
Potassium channels between the astrocyte and the presynaptic terminal make it possible to release K+ ions and avoid accumulation after neuronal activity. Also, the release of neurotransmitters from presynaptic vesicles activates metabotropic receptors on the astrocyte, which then causes the astrocyte's release of gliotransmitters from the cell. [1]
Since bergmann glia appear to persist in the cerebellum, and perform many of the roles characteristic of astrocytes, they have also been called "specialized astrocytes." [9] Bergmann glia have multiple radial processes that extend across the molecular layer of the cerebellar cortex and terminate at the pial surface as a bulbous endfoot. [11]
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates.. CSF is produced by specialized ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations.