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Dose optimization and target attainment of vancomycin in children involves adjusting the dosage to maximize effectiveness while minimizing the risk of adverse effects, specifically acute kidney injury. Dose optimization is achieved by therapeutic drug monitoring (TDM), which allows measurement of vancomycin levels in the blood.
Some other side-effects of vancomycin are nephrotoxicity including kidney failure and interstitial nephritis, blood disorders including neutropenia, and deafness, which is reversible once therapy has stopped. Over 90% of the dose is excreted in the urine, therefore there is a risk of accumulation in patients with renal impairment, so ...
In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors.
Once-daily dosing of aminoglycoside is sufficient to achieve peak plasma concentration for a clinical response without kidney toxicity. Meanwhile, for antibiotics with low volume distribution (vancomycin, teicoplanin, colistin), a loading dose is required to achieve an adequate therapeutic level to fight infections.
Kidney Disease. This is all too common in senior dogs, and since some dogs need to urinate more, they sometimes end up going in the house. It is not that they have to use the house, just that they ...
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
(Reuters) -Four men were convicted in Spain on Sunday in connection with the homophobic murder of a 24-year-old nursing assistant that sparked protests in cities across Spain and abroad.
Kidney failure; Other names: Renal failure, end-stage renal disease (ESRD), stage 5 chronic kidney disease [1] A hemodialysis machine which is used to replace the function of the kidneys: Specialty: Nephrology: Symptoms: Leg swelling, feeling tired, loss of appetite, confusion [2] Complications: Acute: Uremia, high blood potassium, volume ...
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