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Micrograph of the spleen showing darkly stained, spheroid Gamna-Gandy bodies (arrows) outside the vessel wall at the center. Also shown is diffusely scattered, brown, granular hemosiderin pigment (arrowheads), indicating previous hemorrhage (hematoxylin & eosin staining, 40x magnification).
An image of the spleen in the human body. Also shows the red and white pulp regions. Splenocytes are spleen cells and consist of leukocytes like B and T cells, dendritic cells, and macrophages. [2] The spleen is split into red and white pulp regions with the marginal zone separating the two areas. The red pulp is involved with filtering blood ...
Micrograph of hyaloserositis of the spleen (sugar-coated spleen). H&E stain. In pathology, hyaloserositis is the coating of an organ with a fibrous hyaline, [1] resulting from inflammation of the serous membrane covering the organ. [2] The spleen is commonly affected and often referred to as sugar-coated spleen. [3]
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue.
The cords of Billroth (also known as splenic cords or red pulp cords) are found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages.
T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. [5] Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis.
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The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in lymph nodes. [1] [2]