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2. Hepatotoxicity - Wikipedia

   en.wikipedia.org/wiki/Hepatotoxicity

   Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

3. First pass effect - Wikipedia

   en.wikipedia.org/wiki/First_pass_effect

   The liver is the major site of first pass effect; however, it can also occur in the lungs, vasculature or other metabolically active tissues in the body. Notable drugs that experience a significant first pass effect are buprenorphine , chlorpromazine , cimetidine , diazepam , ethanol (drinking alcohol), imipramine , insulin , lidocaine ...

4. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

   www.aol.com/cialis-side-effects-expect-avoid...

   Like other medications for the treatment of (ED), Cialis — and its generic version, tadalafil — can cause adverse effects at first. Fortunately, most tadalafil side effects are mild and ...

5. Grapefruit–drug interactions - Wikipedia

   en.wikipedia.org/wiki/Grapefruit–drug_interactions

   The effects on the CYP3A4 in the liver could, in principle, cause interactions with non-oral drugs (e.g. parenteral, inhaled substances, transdermal), [citation needed] and non-CYP3A4-mediated effects also exist. [31] Cytochrome isoforms affected by grapefruit components include CYP3A4, CYP1A2, CYP2C9, and CYP2D6. [21]

6. Fatty Liver Disease: What Men Need to Know - AOL

   www.aol.com/fatty-liver-disease-men-know...

   Your healthcare provider may recommend medications for fatty liver disease. These include: Metformin. ... Liver enzymes. Body weight. A1C (a measure of blood sugar) ... Staying on top of your health.

7. Combined drug intoxication - Wikipedia

   en.wikipedia.org/wiki/Combined_drug_intoxication

   Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death.

8. Drug metabolism - Wikipedia

   en.wikipedia.org/wiki/Drug_metabolism

   Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...

9. Best Liver Supplements: 5 Best Detoxifying Supplements for ...

   www.aol.com/entertainment/best-liver-supplements...

   The Liver Detox contains a dizzying amount of herbs and minerals, meticulously researched to work both alone and in-tandem to support liver detox, overall liver health and immunity.