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Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [ 5 ] [ 6 ] [ 7 ] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling ) expression.
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. These transcription factors are critical to making sure that genes are expressed in the right cell at the right time and in the right amount, depending on the changing requirements of the organism.
Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. [ 5 ] [ 6 ] The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons .
T-box refers to a group of transcription factors involved in embryonic limb and heart development. [1] Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding.
This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. [1] It was assembled by manual curation. More detailed information is found in the manuscript and the web site accompanying the paper (Human Transcription Factors)
A generic transcription factory during transcription, highlighting the possibility of transcribing more than one gene at a time. The diagram includes 8 RNA polymerases however the number can vary depending on cell type. The image also includes transcription factors and a porous, protein core.
Artificial transcription factors (ATFs) are engineered individual or multi molecule transcription factors that either activate or repress gene transcription (biology). [ 1 ] ATFs often contain two main components linked together, a DNA-binding domain and a regulatory domain, also known as an effector domain or modulatory domain. [ 1 ]
Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG.