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The Hox transcription factor family, for example, is important for proper body pattern formation in organisms as diverse as fruit flies to humans. [24] [25] Another example is the transcription factor encoded by the sex-determining region Y (SRY) gene, which plays a major role in determining sex in humans. [26]
Tbx4 is a transcription factor and member of the T-box family, which have been shown to play important role in fetal development. [14] Tbx4 is expressed in a wide variety of tissues during organogenesis , including the hindlimb, proctodeum, mandibular mesenchyme , lung mesenchyme, atrium of the heart and the body wall. [ 14 ]
T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. [ 5 ] [ 6 ] [ 7 ] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box .
Chromatin Immunoprecipitation sequencing, also known as ChIP-seq, is an experimental technique used to identify transcription factor binding events throughout an entire genome. Knowing how the proteins in the human body interact with DNA to regulate gene expression is a key component of our knowledge of human diseases and biological processes.
The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the DNA-binding domain (DBD or often also abbreviated as BD) and activating domain (AD).
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [ 5 ] [ 6 ] [ 7 ] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling ) expression.
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene. [5] [6] [7] Brachyury functions as a transcription factor within the T-box family of genes. [8] Brachyury homologs have been found in all bilaterian animals that have been screened, as well as the freshwater cnidarian Hydra. [8]
Grainyhead-like genes are a family of highly conserved transcription factors that are functionally and structurally homologous across a large number of vertebrate and invertebrate species. For an estimated 100 million years or more, this genetic family has been evolving alongside life to fine tune the regulation of epithelial barrier integrity ...