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Drug-induced lupus erythematosus is an autoimmune disorder caused by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of systemic lupus erythematosus (SLE). There are 38 known medications to cause DIL but there are three that report the highest number of ...
Until now, the treatment called CAR T-cell therapy has been used only in cancer patients in the UK, but researchers believe it could treat range of diseases including lupus and multiple sclerosis.A
Drug-induced lupus erythematosus is a (generally) reversible condition that usually occurs in people being treated for a long-term illness. Drug-induced lupus mimics SLE. However, symptoms of drug-induced lupus generally disappear once the medication that triggered the episode is stopped.
In a review of 65 individuals with cSLE caused by the drugs cited in the above section "Drug", discontinuing the responsible drug in 100% of cases and treatment with a glucocorticoid in 53.3% of cases, hydroxychloroquine in 8.4% of cases, and cyclophosphamide in 3.3% of cases resulted in improvements in 92.0% of the 63 individuals available for ...
Even if such a treatment becomes available, Buyon said, it’s unlikely to work for everyone with lupus. “We have come to the profound understanding that one drug will not do it all,” she said ...
The oral drug, brepocitinib, did not meet the primary study goal of reduction in disease activity at week 52 in patients of SLE, in which the immune system that normally helps protect the body ...
Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. [1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.
In cancer cells where one part of the interaction experiences a loss-of-function mutation, the other part can be interrupted by drug treatment to induce cell death in cancerous cells. Synthetic lethality is an attractive treatment option in patients with cancer since it there should be minimal / no effect on healthy cells.
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