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Although many antibiotics work this way, the exact mechanism of action of linezolid appears to be unique in that it blocks the initiation of protein production, rather than one of the later steps. [14] As of 2014, bacterial resistance to linezolid has remained low. [15] Linezolid is a member of the oxazolidinone class of medications. [10]
The Group A drugs are currently levofloxacin or moxifloxacin, bedaquiline and linezolid, therefore XDR-TB is MDR/RR-TB that is resistant to a fluoroquinolone and at least one of bedaquiline or linezolid (or both). In a study of MDR-TB patients from 2005 to 2008 in various countries, 43.7% had resistance to at least one second-line drug. [28]
Sutezolid is an investigational new drug that is being evaluated for the treatment of extensively drug-resistant tuberculosis. [1] It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom. Like linezolid, sutezolid is a bacterial protein synthesis inhibitor.
Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. . Released in beta in November 2004, the Google Scholar index includes peer-reviewed online academic journals and books, conference papers, theses and dissertations, preprints, abstracts, technical reports, and other ...
(Reusing this file) Public domain Public domain false false This image of a simple structural formula is ineligible for copyright and therefore in the public domain , because it consists entirely of information that is common property and contains no original authorship.
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