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Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Typically, Free T 4 is the preferred test for hypothyroidism, [69] as Free T 3 immunoassay tests are less reliable at detecting low levels of thyroid hormone, [70] and they are more susceptible to interference. [69] Free T 4 levels will usually be lowered, but sometimes might be normal. [71]
Hypothyroidism is more common in women than in men. [3] People over the age of 60 are more commonly affected. [3] Dogs are also known to develop hypothyroidism, as are cats and horses, albeit more rarely. [13] The word hypothyroidism is from Greek hypo-'reduced', thyreos 'shield', and eidos 'form', where the two latter parts refer to the ...
Initial blood tests often include thyroid-stimulating hormone (TSH) and free thyroxine (T4). [9] Total and free triiodothyronine (T3) levels are less commonly used. [9] If autoimmune disease of the thyroid is suspected, blood tests looking for Anti-thyroid autoantibodies can also be obtained. Procedures such as ultrasound, biopsy and a ...
Iodine deficiency is the most common cause of hypothyroidism worldwide, [53] and the autoimmune disease Hashimoto's thyroiditis is the most common cause in the developed world. [54] Other causes include congenital abnormalities, diseases causing transient inflammation, surgical removal or radioablation of the thyroid, the drugs amiodarone and ...
Further information: Thyroid function tests. Triiodothyronine (T 3) and thyroxine (T 4) can be measured as free T 3 and free T 4, which are indicators of their activities in the body. [74] They can also be measured as total T 3 and total T 4, which depend on the amount that is bound to thyroxine-binding globulin (TBG). [74]
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TSH – A thyroid-stimulating hormone level should be obtained first. If it is suppressed, then the nodule is likely a hyperfunctioning (or "hot") nodule. These are rarely malignant. FNAC – fine needle aspiration cytology is the investigation of choice given a non-suppressed TSH. [27] [28] Imaging – Ultrasound and radioiodine scanning.
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