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Each line shows one of the three possible genotypes. In population genetics, the Hardy–Weinberg principle, also known as the Hardy–Weinberg equilibrium, model, theorem, or law, states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences.
In population genetics, the Wahlund effect is a reduction of heterozygosity (that is when an organism has two different alleles at a locus) in a population caused by subpopulation structure. Namely, if two or more subpopulations are in a Hardy–Weinberg equilibrium but have different allele frequencies, the overall heterozygosity is reduced ...
Additive disequilibrium and z statistic. Additive disequilibrium (D) is a statistic that estimates the difference between observed genotypic frequencies and the genotypic frequencies that would be expected under Hardy–Weinberg equilibrium. At a biallelic locus with alleles 1 and 2, the additive disequilibrium exists according to the equations [1]
A de Finetti diagram. The curved line is the expected Hardy–Weinberg frequency as a function of p.. A de Finetti diagram is a ternary plot used in population genetics.It is named after the Italian statistician Bruno de Finetti (1906–1985) and is used to graph the genotype frequencies of populations, where there are two alleles and the population is diploid.
In 1908, G. H. Hardy and Wilhelm Weinberg modeled an idealised population to demonstrate that in the absence of selection, migration, random genetic drift, allele frequencies stay constant over time, and that in the presence of random mating, genotype frequencies are related to allele frequencies according to a binomial square principle called the Hardy-Weinberg law.
Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. [1] Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size.
The Hardy–Weinberg principle states that within sufficiently large populations, the allele frequencies remain constant from one generation to the next unless the equilibrium is disturbed by migration, genetic mutations, or selection.
In the absence of population structure, Hardy-Weinberg proportions are reached within 1–2 generations of random mating. More typically, there is an excess of homozygotes, indicative of population structure. The extent of this excess can be quantified as the inbreeding coefficient, F. Individuals can be clustered into K subpopulations.