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The chromosomal location of BRCA1 was discovered by Mary-Claire King's team at UC Berkeley in 1990. [21] After an international race to refine the precise location of BRCA1, [22] the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics.
Human: Mouse: Entrez: Ensembl: UniProt RefSeq (mRNA) NM_001261840 NM_001329112 ... BRISC and BRCA1-A complex member 2 is a protein in humans encoded by the BABAM2 gene.
A negative test result, if a specific mutation is known to be present in the family, shows that the person does not have a BRCA-related predisposition for cancer, although it does not guarantee that the person will not develop a non-hereditary case of cancer. By itself, a negative test result does not mean that the patient has no hereditary ...
BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of ...
Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ). [7] The role of BRCA1-A complex appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it ...
237911 Ensembl ENSG00000136492 ENSMUSG00000034329 UniProt Q9BX63 Q5SXJ3 RefSeq (mRNA) NM_032043 NM_178309 RefSeq (protein) NP_114432 NP_840094 Location (UCSC) Chr 17: 61.68 – 61.86 Mb Chr 11: 85.95 – 86.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. Function ...
BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. [5] [6] [7] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).
BRCC36, the protein product of the BRCC3 gene, is a deubiquitinating enzyme and a core component of the deubiquitin complex BRCA1-A. [8] BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks.