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The U.S. Institute of Medicine (IOM) sets tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of copper the adult UL is set at 10 mg/day. [4] Copper gluconate is sold as a dietary supplement to provide copper. The typical dose is 2.0 mg copper per day.
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Manganese superoxide dismutase (MnSOD) is the principal antioxidant in mitochondria. Several enzymes activated by manganese contribute to the metabolism of carbohydrates, amino acids, and cholesterol. [2] A deficiency of manganese causes skeletal deformation in animals and inhibits the production of collagen in wound healing. [3]
Soils that are naturally deficient in copper often require copper supplements before agricultural crops, such as cereals, can be grown. [citation needed] Copper deficiencies in soil can lead to crop failure. Copper deficiency is a major issue in global food production, resulting in losses in yield and reduced quality of output.
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Copper deficiency, or hypocupremia, is defined as insufficient copper to meet the body's needs, or as a serum copper level below the normal range. [1] Symptoms may include fatigue , decreased red blood cells , early greying of the hair, and neurological problems presenting as numbness , tingling, muscle weakness, and ataxia . [ 2 ]
The generally accepted trace elements are iron, chlorine, cobalt, copper, zinc, manganese, molybdenum, iodine, selenium, [5] and bromine; [6] there is some evidence that there may be more. The four organogenic elements, namely carbon , hydrogen , oxygen , and nitrogen ( CHON ), that comprise roughly 96% of the human body by weight, [ 7 ] are ...
In the 1930s and 1940s, some scientific and clinical evidence suggested that there might be beneficial uses of vitamins C, E, and niacin in large doses. Beginning in the 1930s in Canada , a megadose vitamin E therapy for cardiovascular and circulatory complaints was developed by Evan Shute and colleagues, named the "Shute protocol". [ 15 ]
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