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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]
The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]
Viagra could lead to more serious side effects, such as: Priapism (a painful, long-lasting arousal) Vision loss. Chest pain. Flu-like symptoms. Heart attack. Stroke. Dizziness. Sudden low blood ...
For example, a small study of 20 people that looked into Viagra’s effect on refractory time found that a standard 100mg dose of sildenafil citrate reduced the average male post-intimacy recovery ...
Viagra has made its way into medicine cabinets the world over as a trusted medication for ED and cardiovascular health. We know intimate activity is supposed to be somewhat off the cuff, but you ...
Until 2014, the U.S. Code of Federal Regulations required that certain drugs and biological products be labelled specifically with respect to their effects on pregnant populations, including a definition of a "pregnancy category". These rules were enforced by the FDA, and medications that have been studied for their effects in pregnancy fell ...
Viagra (sildenafil). Sildenafil, or generic Viagra, provides relief from ED for around four hours. Cialis (tadalafil). Tadalafil is a long-lasting medication that can provide relief from ED for up ...