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The injection should be made with a tuberculin syringe, with the needle bevel facing upward. When placed correctly, injection should produce a pale wheal of the skin, 6 to 10 mm in diameter. The result of the test is read after 48–96 hours, ideally after 72 hours/3rd day. This procedure is termed the 'Mantoux technique'.
In 2010 the Xpert MTB/RIF test, another NAAT for TB, became commercially available and, as the CDC said in 2015, [10] it began "revolutionizing tuberculosis (TB) control by contributing to the rapid diagnosis of TB disease and drug resistance. The test simultaneously detects Mycobacterium tuberculosis complex (MTBC) and resistance to rifampin ...
After exposure, it usually takes 8 to 10 weeks before the TB test would show if someone had become infected." [ 5 ] Depending on ventilation and other factors, these tiny droplets [from the person who has active tuberculosis] can remain suspended in the air for several hours.
Diagnosis of latent TB relies on the tuberculin skin test (TST) or blood tests. [10] Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin (BCG) vaccine. [3] [4] [5] Those at high risk include household, workplace, and social contacts of people with ...
No TB exposure Not infected: No history of exposure Negative reaction to tuberculin skin test 1: TB exposure No evidence of infection: History of exposure Negative reaction to tuberculin skin test 2: TB infection No disease: Positive reaction to tuberculin skin test Negative bacteriologic studies (if done) No clinical, bacteriologic, or ...
T-SPOT.TB, a form of ELISpot, the variant of ELISA (licensed in Europe, US, Japan and China). [3] The former test quantitates the amount of IFN-γ produced in response to the ESAT-6 and CFP-10 antigens from Mycobacterium tuberculosis, which are distinguishable from those present in BCG and most other non-tuberculous mycobacteria.
The equivalent Mantoux test positive levels done with 10 TU (0.1 mL 100 TU/mL, 1:1000) are 0–4 mm induration (Heaf 0-1) 5–14 mm induration (Heaf 2) >15 mm induration (Heaf 3-4) The Mantoux test is preferred in the United States for the diagnosis of tuberculosis; multiple puncture tests, such as the Heaf test and Tine test, are not recommended.
The test may enable the diagnosis of TB in patients likely to be missed by traditional tests. [ 4 ] [ 5 ] According to the Centers for Disease Control and Prevention (CDC) in 2015, [ 6 ] the Xpert MTB/RIF test was "revolutionizing TB control by contributing to the rapid diagnosis of TB disease and drug resistance.