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DT-PACE refers to a chemotherapy regimen for multiple myeloma consisting of Dexamethasone, Thalidomide, Cisplatin or Platinol, Adriamycin or doxorubicin, Cyclophosphamide, and Etoposide. [ 1 ] References
Folkman persuaded the patient's doctor to try thalidomide, and that doctor conducted a clinical trial of thalidomide for people with multiple myeloma in which about a third of the subjects responded to the treatment. [67] The results of that trial were published in the New England Journal of Medicine in 1999. [67] [72]
The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.
Other areas of concentration include bone marrow transplants, stem cell transplantation, lymphoma, leukemia, multiple myeloma, neuro-oncology, cutaneous malignancy, gastrointestinal, geriatric, head and neck, thoracic, urologic, breast, and gynecologic. [2] As of 2023, Andre Goy is chair and Chief Physician Officer. [3] [4] [5]
Cancer Treatment Centers of America (CTCA) was founded in 1988 by Richard J. Stephenson following the death of his mother, Mary Brown Stephenson, who died from lung cancer. [3] Stephenson purchased the American International Hospital in Zion, Illinois , in 1988 and expanded the hospital to include a radiation center, the Mary Brown Stephenson ...
The MMRC Multiple Myeloma Genomics Initiative comprehensive genomic analysis program. It was designed to rapidly accelerate progress made against multiple myeloma by significantly improving the understanding of the biology of the disease.
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