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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the efficiency of axonal impulse conduction. [ 2 ] In humans, point mutations in PLP are the cause of Pelizaeus–Merzbacher disease (PMD), a neurologic disorder of myelin metabolism.
Myelin's best known function is to increase the rate at which information, encoded as electrical charges, passes along the axon's length. Myelin achieves this by eliciting saltatory conduction. [1] Saltatory conduction refers to the fact that electrical impulses 'jump' along the axon, over long myelin sheaths, from one node of Ranvier to the next.
Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function.
A nerve tissue protein is a biological molecule related to the function and maintenance of normal nervous tissue. [1] An example would include, for example, the generation of myelin which insulates and protects nerves.
The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. . Myelin protein zero, absent in the central nervous system, [14] is a major component of the myelin sheath in peripheral nerv
18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. Myelin protein P2 is a ...