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Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects. [20] At anesthetic doses, ketamine induces a state of dissociative anesthesia, a trance-like state providing pain relief, sedation, and amnesia. [21]
Ketamine and nitrous oxide are club drugs. Phencyclidine (PCP or angel dust) is available as a street drug. Dextromethorphan -based cough syrups (often labeled DXM) are taken by some users in higher than medically recommended levels for their dissociative effects.
Ketamine, one of the most popular NMDA receptor antagonists. NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor . They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia.
According to the United States Drug Enforcement Administration (DEA), ketamine is a "dissociative anesthetic that has some hallucinogenic effects" and "can induce a state of sedation, immobility ...
But Feifel said the drug’s dissociative and hallucinogenic properties — which made it such a popular party drug — may hold the key to why it helps some people with depression and other ...
Ketamine is defined as a dissociative anesthetic with some hallucinogenic effects by the U.S. Drug Enforcement Administration. The medication alters the perception of sight and sound, making users ...
Some people also snort or inject ketamine recreationally to experience euphoric or “dissociative” effects that cause someone to feel separated from their own body, Goodman-Meza said.
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.