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Metoprolol is classified as a moderately lipophilic beta blocker. [37] More lipophilic beta blockers tend to cross the blood–brain barrier more readily, with greater potential for effects in the central nervous system as well as associated neuropsychiatric side effects. [37] Metoprolol binds mainly to human serum albumin with an unbound ...
The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, commonly called the Beers List, [1] are guidelines published by the American Geriatrics Society (AGS) for healthcare professionals to help improve the safety of prescribing medications for adults 65 years and older in all except palliative settings.
Therefore, blocking β 2-adrenoceptors lowers plasma glucose. β 1-blockers have fewer metabolic side effects in diabetic patients; however, the fast heart rate that serves as a warning sign for insulin-induced low blood sugar may be masked, resulting in hypoglycemia unawareness. This is termed beta blocker-induced hypoglycemia unawareness ...
The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive.
This in turn may result in fewer effects in the central nervous system as well as a lower risk of neuropsychiatric side effects. [44] Only small amounts of atenolol are said to enter the brain. [2] [3] The brain-to-blood ratio of atenolol was 0.2 : 1 in one study, whereas the ratio for propranolol was 33 : 1 in the same study. [3]
Nadolol is used to treat hypertension and for long-term treatment of angina pectoris and is approved by the FDA for these purposes. [8]It is regularly used off-label [8] for control of heart rate in people with atrial fibrillation, [9] prevention of migraine headaches; [10] prevention of bleeding veins in people with portal hypertension caused by cirrhosis; [4] and to treat people with high ...
Elderly people are also at a heightened risk for developing TD, [10] as are females and those with organic brain injuries or diabetes mellitus and those with the negative symptoms of schizophrenia. [25] TD is also more common in those that experience acute neurological side effects from antipsychotic drug treatment. [25]
Common side effects include headache, feeling tired, diarrhea, and swelling in the legs. [7] More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. [9] There are concerns that use during pregnancy may be harmful to the baby. [10]
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