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IAG933 is an investigational new drug that is being evaluated for the treatment of cancer. [1]IAG933 is a small molecule inhibitor developed by Novartis Pharmaceuticals to directly disrupt the YAP/TAZ-TEAD protein-protein interaction, a critical mediator of oncogenic signaling in the Hippo pathway.
Neopentane, also called 2,2-dimethylpropane, is a double-branched-chain alkane with five carbon atoms. Neopentane is a flammable gas at room temperature and pressure which can condense into a highly volatile liquid on a cold day, in an ice bath, or when compressed to a higher pressure.
Download QR code; Print/export ... 3D model . Interactive image; ChEMBL: ... Neopentyl alcohol is a compound with formula (CH 3) 3 CCH 2 OH. It is a colorless solid.
Neopentylamine is an organic compound with the molecular formula (CH 3) 3 CCH 2 NH 2. It is a colorless liquid. The molecule is the primary amine derivative of neopentane, (CH 3) 4 C. Like most alkyl amines, it degrades slowly in air. [1]
Pentane is an organic compound with the formula C 5 H 12 —that is, an alkane with five carbon atoms. The term may refer to any of three structural isomers, or to a mixture of them: in the IUPAC nomenclature, however, pentane means exclusively the n-pentane isomer, in which case pentanes refers to a mixture of them; the other two are called isopentane (methylbutane) and neopentane ...
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Efficacy was evaluated in a single-arm cohort of an open-label, multicenter trial (SNDX-5613-0700, NCT04065399; AUGMENT-101) in 104 adult and pediatric participants (at least 30 days old) with relapsed or refractory (R/R) acute leukemia with a lysine methyltransferase 2A gene translocation. [3]
The clinical development program for NV-5138 began with a Phase 1 trial initiated by Navitor Pharmaceuticals in 2018. [ 1 ] [ 7 ] This initial study was designed to evaluate the safety, tolerability, and pharmacokinetics of the compound in both healthy volunteers and patients diagnosed with TRD.