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Download QR code; Print/export Download as PDF; Printable version; In other projects ... RAF-1 is between RAS and MEK just above the centre of the diagram.
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme [4] that in humans is encoded by the RAF1 gene. [ 5 ] [ 6 ] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. [ 7 ]
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The RAF 1 is a British air-cooled, V-8 engine developed for aircraft use during World War I. Based on a French design, it was developed at the Royal Aircraft Factory , and built by six different British companies including Daimler , Rolls-Royce and Wolseley Motors Limited .
B-Raf is a 766-amino acid, regulated signal transduction serine/threonine-specific protein kinase.Broadly speaking, it is composed of three conserved domains characteristic of the Raf kinase family: conserved region 1 (CR1), a Ras-GTP-binding [11] self-regulatory domain, conserved region 2 (CR2), a serine-rich hinge region, and conserved region 3 (CR3), a catalytic protein kinase domain that ...
Compared to the other members of this family (Raf-1 and B-Raf), very little is known about A-Raf. It seems to share many of the properties of the other isoforms, but its biological functions are not as thoroughly researched. All three Raf proteins are involved in the MAPK signaling pathway.
raf 1 The Renault 70 hp, ( 8Ab , 8C ) was a French V-8 aero engine that first ran in 1910. The type powered many early military aircraft including the Farman MF.7 Longhorn and the Royal Aircraft Factory B.E.2 .
No. 182 Wing RAF: 1 August 1943: Chittagong, India: 1 August 1945 [11] No. 183 Wing RAF: 1 January 1944: Ridgeway, Ceylon: 30 December 1945 [11] No. 250 Wing RAF: 25 August 1939: Ismailia, Egypt: 6 December 1942 [11] No. 276 Wing RAF: 1 August 1942: Heliopolis: 31 August 1945 [12] No. 296 Wing RAF: 17 February 1942: Freetown, West Africa: 30 ...